发明名称 |
METHODS OF THERAPY FOR B-CELL MALIGNANCIES USING ANTAGONIST ANTI-CD40 ANTIBODIES |
摘要 |
Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity when the antibody binds a CD40 antigen on a normal human B cell, exhibits antagonist activity when the antibody binds a CD40 antigen on a malignant human B cell, and can exhibit antagonist activity when the antibody binds a CD40 antigen on a normal human B cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of malignant human B cells. |
申请公布号 |
WO0228481(A3) |
申请公布日期 |
2003.03.06 |
申请号 |
WO2001US30963 |
申请日期 |
2001.10.02 |
申请人 |
CHIRON CORPORATION;CHU, KETING;MASUOKA, LORIANNE |
发明人 |
CHU, KETING;MASUOKA, LORIANNE |
分类号 |
C12N15/09;A61K39/395;A61P1/04;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P35/00;A61P37/00;A61P37/02;A61P37/06;A61P43/00;C07K16/18;C07K16/28;C07K16/30;C12N15/13;C12P21/08 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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