COMPOSITIONS CONTAINING ITRACONAZOLE AND THEIR PREPARATION METHODS
摘要
The present invention relates to compositions containing itraconazole with a greatly increased bioavailability and their preparation methods. More specifically, the present invention relates to compositions containing itraconazole which is a sparingly-soluble drug, fatty acid or fatty alcohol and surfactant and their preparation methods. Compositions according to the present invention act as Self-MicroEmulsifying Drug Delivery System(SMEDDS) wherein itraconazole which is a sparingly-soluble drug is dissolved and dispersed to form a mocoidal phase, and the mocoidal phase is dissolved in water to form microemulsion. And because of increased dissolution property and increased bioavailability, compositions according to the present invention show equal efficacy using less amount than commercial pharmaceutical preparations such as sporanox capsule and are cheaper rather than the commercial pharmaceutical preparations such as sporanox capsule.
申请公布号
WO03017986(A1)
申请公布日期
2003.03.06
申请号
WO2002KR01593
申请日期
2002.08.23
申请人
WON JIN BIOPHARMA CO., LTD.;LEE, BEOM, JIN;LEE, DONG, WON;CHOI, CHOON, YOUNG