USE OF ESTROGENIC COMPOUNDS IN COMBINATION WITH PROGESTOGENIC COMPOUNDS IN HORMONE-REPLACEMENT THERAPY

摘要

One aspect of the present invention relates to method of hormone replacement in mammals, which method comprises the parenteral or rectal administration of an estrogenic component and a progestogenic component to a mammal in an amount effective to treat or prevent symptoms of hypoestrogenism, wherein the estrogenic component is selected from the group consisting of: substances represented by the following formula (I) in which formula R>1<, R>2<, R>3<, R>4< independently are a hydrogen atom, a hydroxyl group or an alokxy group with 1-5 carbon atoms; each of R>5<, R>6<, R>7<, is a hydroxyl group; and no more than 3 of R>1<, R>2<, R>3<, R>4< are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors. Another aspect of the invention concerns a drug delivery system for parenteral or rectal administration that contains the aforementioned estrogenic component and an androgenic component, said drug delivery system being selected from the group consisting of suppositories, systems for intravaginal delivery, inhalers, nasal sprays and transdermal delivery systems.