发明名称 |
4-substituted-1- (arylmethylidene) thiosemicarbazide, 4-substituted-1- (arylcarbonyl) thiosemicarbazide and analogs as activators of caspases and inducers of apoptosis and the use thereof |
摘要 |
The present invention is directed to optionally substituted 4-substituted-1-(arylmethylidene)thiosemicarbazide, 4-substituted-1-(arylcarbonyl)thiosemicarbazide and analogs thereof, represented by the Formulae I and II: wherein A1, A2, Q and R1-R3 are defined herein. The present invention also relates to the discovery that compounds having Formulae I and II are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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申请公布号 |
US2003045581(A1) |
申请公布日期 |
2003.03.06 |
申请号 |
US20020158827 |
申请日期 |
2002.06.03 |
申请人 |
CAI SUI XIONG;NGUYEN BAO NGOC;DREWE JOHN;REDDY P. SANJEEVA;KASIBHATLA SHAILAJA;PERVIN AZRA |
发明人 |
CAI SUI XIONG;NGUYEN BAO NGOC;DREWE JOHN;REDDY P. SANJEEVA;KASIBHATLA SHAILAJA;PERVIN AZRA |
分类号 |
A61K31/175;A61K31/435;A61K31/44;A61K31/4965;C07C281/14;C07C337/08;C07D207/32;C07D207/335;C07D213/53;C07D213/61;C07D213/84;C07D213/86;C07D231/16;C07D233/54;C07D277/28;C07D277/56;C07D285/06;C07D295/135;C07D307/52;C07D307/76;C07D333/22;C07D333/44;(IPC1-7):A61K31/175;A61K31/496 |
主分类号 |
A61K31/175 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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