发明名称 |
Backbone modified oligonucleotide analogues |
摘要 |
Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.
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申请公布号 |
US2003045705(A1) |
申请公布日期 |
2003.03.06 |
申请号 |
US20020153320 |
申请日期 |
2002.05.22 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
COOK PHILLIP DAN;SANGHVI YOGESH SHANTILAL;VASSEUR JEAN JACQUES;DEBART FRANCOISE |
分类号 |
A61K47/48;A61K49/00;C07D405/04;C07D405/14;C07F7/18;C07H19/04;C07H19/06;C07H19/10;C07H19/16;C07H21/00;(IPC1-7):C07H21/04 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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