| 摘要 |
3,6-Diamino-2,3,4,5-tetrahydro-1,3,5-triazin-2-one derivatives (I) are new. 3,6-Diamino-3,4,5,6-tetrahydro-1,3,5-triazin-2-one derivatives of formula (I) and their salts, solvates and hydrates are new. R<1>, R<2> = H or 1-6C alkyl; A = NR<4>R<5>, NR<5>-CQ-NR<6>R<7> or NR<5>-CR<8>=NR<9>; R<4>-R<7> = H, 1-6C alkyl, 1-6C alkanoyl, benzyl or pyridylmethyl; R<8> = H or 1-6C alkyl; Q = O, S or NR<9>; R<9> = H, 1-6C alkyl, 1-6C alkanoyl, benzyl or pyridylmethyl; D = 2-6C alkanediyl optionally substituted with 1-2 of OH, 1-6C alkoxy or 1-6C alkanoyloxy or with an oxo group; E = a bond or CH2; R<3> = H, NH2, acetylamino, 1-6C alkyl or 3-7C cycloalkyl. Independent claims are also included for: (1) a process for preparing compounds (I); and (2) medicaments comprising compounds (I) and excipients.
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