Verfahren zur Herstellung von 6-Keto-20-hydroxysteroiden

摘要

Cholest-6-one-20-ols Compds. of formula: (and wherein R2 is H or OH, Y1 is lower alkyl or lower alkynyl which can be substituted in the 25-position with etherified or esterified hydroxy, C1-C8 is a saturated or unsaturated C-C bond and A is the A ring in the steroid nucleus; which can also contain an OH or lower alkanoyloxy substituent in the 2- and 3-positions or an isopropylidenedioxy in the 2,3-positions or an oxo moiety in the 3- position) and is prepared by reacting a compound of the formula: with an alkali metal acetylide or a compound of formula Y.MgX (wherein Y is lower alkyl or alkynyl which may be substituted in the 4-position with etherified or esterified hydroxy and X is Cl, Br or I) may be converted into known insect metamorphosis hormones.