发明名称 |
Taxane derivatives, preparation containing them and their use |
摘要 |
<p>Provided herein is a taxane having a hydrocarbon attached at the 2 and/or 7 positions, the hydrocarbon's alpha position being occupied by a "hydrolysis-promoting group" ("HPG"). Substitution of an HPG for the methylene unit ordinarly occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers.</p> |
申请公布号 |
SK283199(B6) |
申请公布日期 |
2003.03.04 |
申请号 |
SK19980000334 |
申请日期 |
1996.09.12 |
申请人 |
THE LIPOSOME COMPANY, INC. |
发明人 |
MAYHEW ERIC;ALI SHAUKAT;JANOFF ANDREW S. |
分类号 |
A61K9/127;A61K31/337;A61P35/00;C07D305/14;(IPC1-7):C07D305/14;A61K31/335 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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