发明名称 |
Morphine sulphate microgranules, method for preparing same and compositions containing same. |
摘要 |
Prolonged release morphine sulfate (I) microgranules, comprising neutral carrier particles coated with an active layer and a prolonged release layer, is new. The prolonged release layer contains (a) a methacrylic acid-methyl methacrylate copolymer in which the ratio of free carboxy groups to ester groups is 0.5; and (b) hydrophobic silica. Independent claims are included for: (A) the preparation of the microgranules, by applying the active layer and prolonged release layers to the carrier particles, by coating in aqueous solution; and (B) pharmaceutical compositions containing the microgranules. |
申请公布号 |
ZA200110087(B) |
申请公布日期 |
2003.03.03 |
申请号 |
ZA20010010087 |
申请日期 |
2001.12.07 |
申请人 |
LABORATOIRES DES PRODUITS ETHIQUES ETHYPHARM |
发明人 |
DOMINIQUE MARECHAL;PACAL OURY;PASCAL SUPLIE |
分类号 |
A61K9/16;A61K9/50;A61K9/52;A61K31/485;A61K47/00;A61K47/02;A61K47/32;A61P23/00;A61P25/04 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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