| 摘要 |
A method of forming an array of electrically addressable cells includes the steps of (a) forming a set of parallel conductor strips extending in a first direction on an insulating substrate; (b) forming an insulating layer superimposed on the first series of parallel strips; and (c) forming a second set of parallel conductor strips extending in a direction at right angles to the first direction superimposed on the insulating layer so as to form crossover regions between the strips. Thereafter, (d) wells are formed in the structure which extend through the conductor strips so that the wells at the crossover regions can be addressed electrically in the conductor strips. The addressable array of cells can then be used for selectively reacting a substance with a series of different reagents by a method which involves addressing selected groups of cells with electrical signals using the matrix of conductor strips. An electrolyte is applied to the array in such a way that the selected cells can be either shuttered by gas bubbles formed by the electrolyte, to protect them from reaction, or can be subjected to a local change in pH which promotes a reaction. In this way, a matrix of chemicals can be synthesized so that the composition and spatial position is known for each component of the matrix. |
