NOVOS METODOS DE VACINACAO E CONSEQUENTES VACINAS QUE COMPREENDEM UM ACIDO NUCLEICO QUE CODIFICA UM PRIMEIRO EPITOPO E UM PEPTIDO QUE CONTEM UM SEGUNDO EPITOPO

摘要

The invention relates to methods of and compositions for vaccinating a mammal against a disease, wherein a mixture is administered which includes (i) a nucleic acid which encodes a first epitope and (ii) a peptide containing a second epitope such that both of the nucleic acid and the second epitope are taken up by and the nucleic acid is expressed in a professional antigen presenting cell of the mammal, and the first and second epitopes are processed in the cell such that an immune response is elicited in the mammal to the epitopes.