Conjugates of DNA interacting groups with steroid hormones for use as nucleic acid transfection agents

摘要

A compound comprising a steroid hormone selected from the group consisting of glucocorticoids, mineralcorticoids and androgens, linked to a DNA-interacting molecule via a spacer of 5-15atoms. The spacer is linked to both the steroid hormone and the DNA-interacting molecule via urethane bonds. The compound can be complexed with a nucleic acid molecule and used to introduce the nucleic acid molecule into the nucleus of a cell.