| 摘要 |
The invention presents two embodiments of a process for preparing a composition for collagen membranes. In a first embodiment, the collagenic paste extracted from bovine derma is shredded and homogenized up to 9,000 ... 11, 000x 1,000 rpm, gradually adding distilled water wherein hydrosoluble active substance were introduced, depending on the final purpose of the composition ; after a complete homogenization, which is judged when a transparent solution is obtained, the rotative speed decreases to 0.3 ... 0.1 X 1000 rpm and the solution is left, while continuously stirring until the complete deaeration. In a second embodiment, the preset amount of collagen for preparing the membrane composition is subjected to a slight and continuous stirring on a steam bath, at a temperature in the range of 37 ... 45 degree C, till the collagenic network is reversibly broken out to a pH = 3.5 ... 4, there being also achieved the complete deaeration; the resulting solution is homogenized then with a pre-established distilled water volume, wherein the active substances were solubilized at a low rotative speed of 0.3 ... 0.1 X 1000 rpm.
|
