| 摘要 |
Oxidn. dye compsns. for dyeing keratinic fibres, esp. human hair, contain 3-substd. 4,5-diamino-pyrazoles of formula (I) or their acid-addn. salts as developers. R1-R5 = H; 1-6C alkyl; 2-4C hydroxyalkyl or aminoalkyl; phenyl opt. substd. by halo, 1-4C alkyl, 1-4C alkoxy, NO2, CF3, NH2 or 1-4C alkylamino; benzyl opt. substd. by halo, 1-4C alkyl, 1-4C alkoxy, methylenedioxy or NH2; or (CH2)mX(CHY)nZ; or R3 can also = NH2 or 1-4C alkylamino when R2 = H; m, n = 1-3; X = O or NH; Y = H or Me; Z = Me, OR or NRR'; R, R' = H, Me or Et; R6 = 1-6C alkyl; 1-4C hydroxyalkyl, 1-4C aminoalkyl; mono- or di(1-4C alkyl)amino(1-4C alkyl); (1-4C hydroxyalkyl)amino(1-4C alkyl); (1-4C alkoxy)methyl; phenyl opt. substd. by halo, 1-4C alkyl, 1-4C alkoxy, NO2, CF3, NH2 or 1-4C alkylamino; benzyl opt. substd. by halo, 1-4C alkyl, 1-4C alkoxy, methylenedioxy or NH2; thienyl, furyl or pyridyl; or (CH2)pO(CH2)qOR"; p, q = 1-3; R" = H or Me; provided that: (a) at least one of R2-R5 = H; (b) only one of R2 and R3, and only one of R4 and R5, can be opt. substd. phenyl, benzyl or (CH2)mX(CHY)nZ; (c) when R4 = R5 = H, then R1+R2+R3 can form a hexahydropyrimidine or tetrahydroimidazole ring opt. substd. by 1-4C alkyl or 1,2,4-tetrazolyl; and (d) when R2-R5 = H or 1-6C alkyl, then R1 or R6 may also = 2-, 3- or 4-pyridyl, 2- or 3-thienyl or 2- or 3-furyl gp. opt. substd. by Me or a cyclohexyl gp. Cpds. (I) are new when: (i) R6 is not hydroxymethyl, isobutyloxymethyl, methoxyethoxymethyl, cyclohexyl, thienyl, pyridyl, phenyl, methylphenyl, trifluoromethylphenyl or chlorophenyl when R1 = Me, R2, R4 and R5 = H and R3 = H or Me; (ii) R6 is not Ph when R1 = Ph and R2-R5 = H; (iii) R3 is not H, Me or Ph when R1 = Ph, R2, R4 and R5 = H and R6 = Me; (iv) R3 is not Ph when R1 = Ph, R2 = Me or Et, R4 and R5 = H and R6 = Me; (v) R4 is not Me when R1 = Ph, R2, R3 and R5 = H and R6 = Me; (vi) R1 is not chlorophenyl, trifluoroethyl-phenyl, nitrophenyl or pyridyl when R2-R5 = H and R6 = Me; (vii) R3 is not H, 1-4C alkyl or Ph when R1, R2, R3 and R5 = H and R6 = phenyl opt. substd. by Cl, Me or OMe; (viii) R6 is not Me when R1-R5 = H; (ix) R6 is not Me or Ph when R1 = beta -hydroxyethyl and R2-R5 = H; (x) R6 is not phenyl opt. substd. by Me, Et, OMe or Cl when R4 = Me, R5 = Ph, R2 and R3 = H and R1 = H or Me; (xi) R6 is not Me when R1 = t-Bu and R2-R5 = H; (xii) R6 is not Me or Ph when R1 = pyridyl, R2, R4 and R5 = H and R3 = H or Me; (xiii) R6 is not Me when R1 = Me, Et or 4-aminophenyl, R2, R4 and R5 = H and R3 = H or Ph; (xiv) R3 and/or R6 is not Me when R1 = i-Pr and R2, R4 and R5 = H; and (xv) R6 is not Me or Ph when R1 = H or Ph, R2, R4 and R5 = H and R3 = benzyl, methylphenyl or chlorophenyl. |
