发明名称 |
ANTAGONISTIC ANTI-HTNFSF13B HUMAN ANTIBODIES |
摘要 |
<p>Human monoclonal antibodies that specifically bind to TNFSF13b polypeptides are disclosed. These antibodies have high affinity for hTNFSF13b (e.g., KD = 10-8 M or less), a slow off rate for TNFSF13b dissociation (e.g., Koff = 10- 3 sec-1 or less) and neutralize TNFSF13b activity in vitro and in vivo. The antibodies of the invention are useful in one embodiment for inhibiting TNFSF13b activity in a human subject suffering from a disorder in which hTNFSF13b activity is detrimental. Nucleic acids encoding the antibodies of the present invention, as well as, vectors and host cells for expressing the m are also encompassed by the invention.</p> |
申请公布号 |
CA2452447(A1) |
申请公布日期 |
2003.02.27 |
申请号 |
CA20022452447 |
申请日期 |
2002.08.15 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
RATHNACHALAM, RADHAKRISHNAN;KIKLY, KRISTINE KAY;WITCHER, DERRICK RYAN;GELFANOVA, VALENTINA PAVLOVNA;HALE, JOHN EDWARD |
分类号 |
C12N15/09;A61K39/395;A61P1/04;A61P11/06;A61P15/00;A61P17/02;A61P17/06;A61P19/02;A61P29/00;A61P31/04;A61P35/00;A61P37/02;A61P37/08;C07K16/24;C07K16/28;C12P21/08;(IPC1-7):C12N15/13 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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