发明名称 |
Self antigen vaccines for treating B cell lymphomas and other cancers |
摘要 |
A polypeptide self-antigen useful in a tumor-specific vaccine mimics one or more epitopes of an antigen uniquely expressed by cells of the tumor. The polypeptide is preferably produced in a plant that has been transformed or transfected with nucleic acid encoding the polypeptide and is obtainable from the plant in correctly folded, preferably soluble form without a need for denaturation and renaturation. This plant-produced polypeptide is immunogenic without a need for exogenous adjuvants or other immunostimulatory materials. The polypeptide is preferably an scFv molecule that bears the idiotype of the surface immunoglobulin of a non-Hodgkin's (or B cell) lymphoma. Upon administration to a subject with lymphoma, the plant-produced, tumor-unique scFv polypeptide induces an idiotype-specific antibody or cell-mediated immune response against the lymphoma.
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申请公布号 |
US2003039659(A1) |
申请公布日期 |
2003.02.27 |
申请号 |
US20020067892 |
申请日期 |
2002.02.08 |
申请人 |
MCCORMICK ALISON A.;TUSE DANIEL;REINL STEPHEN J.;LINDBO JOHN A.;TURPEN THOMAS H. |
发明人 |
MCCORMICK ALISON A.;TUSE DANIEL;REINL STEPHEN J.;LINDBO JOHN A.;TURPEN THOMAS H. |
分类号 |
C07K16/00;C12N15/82;(IPC1-7):A61K39/00;C07K14/435;A01H1/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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