发明名称 |
PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED N-ACYL-BETA-AMINO ACID DERIVATIVES BY ENANTIOSELECTIVE HYDROGENATION OF THE CORRESPONDING (Z)-ENAMIDES |
摘要 |
A process for the preparation of an enantiomerically enriched beta-amino acid derivative of formula (1), or the opposite enantiomer thereof, wherein R1 is an optionally substituted alkyl, aryl or heteroaryl group of up to 20 C atoms, R2 is ann alkyl group of up to 20 C atoms, and R3 is H or an alkyl or aryl group of up to 20 C atoms, which comprises asymmetric hydrogenation of the (z)-enamide precursor (2) in an alcohol solvent or cosolvent, catalysed by a cationic rhodium complex of a chiral phosphine ligand having the partial formula (3), wherein n is 0 to 6 and R represents at least one non-hydrogen organic group of up to 20 C atoms. |
申请公布号 |
WO03016264(A1) |
申请公布日期 |
2003.02.27 |
申请号 |
WO2002US26142 |
申请日期 |
2002.08.16 |
申请人 |
DOW GLOBAL TECHNOLOGIES INC.;MALAN, CHRISTOPHE, GUILLAUME;COBLEY, CHRISTOPHER |
发明人 |
MALAN, CHRISTOPHE, GUILLAUME;COBLEY, CHRISTOPHER |
分类号 |
C07B61/00;C07C231/12;C07C231/18;C07C233/47;C07C233/51;C07C233/83 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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