| 摘要 |
<p>A method is defined wherein a Master Library of individual compounds, mixtures of compounds, or reaction pre-mixtures in solvent are prepared for storage and subsequent utilization in a Distribution-Ready Library by delivery of the master stock constituents into a distribution formulation liquid (DFL). The individual compounds within the Master Library can include peptides, proteins, organic chemicals, pharmaceutical compounds, RNA, DNA, or cell fractions. The Distribution-Ready Library can be maintained indefinitely in storage. At the time of manufacture or time of need, the Distribution-Ready Library is microarrayed onto substrates at high density, thereby creating numerous Library Microarrays that are identical replicates of the Master Library compound(s) in DFL at fixed and known positions on the substrate. The DFL has a defined surface tension to maintain the Master Library compound in a non-spreading, non-beading adherent microdot, or spot, at a fixed position on the substrate in a manner that is stable for extended periods of time.</p> |
