Novel substituted tricyclic compounds

摘要

Compounds of the general formula (I) are useful in the treatment and prevention of beta3-related diseases including diabetes, obesity and hyperlipidemia wherein R1 is hydrogen, halogen, or hydroxyl; R2 is C1-4 alkyl or benzyl; R3 is OR, halogen, trifluoromethyl, C1-8 alkyl, lower acyl, NR4R4', nitro, or cyano; R is hydrogen, C1-8 alkyl, benzyl group, or optionally substituted lower acyl; R4 and R4' are each independently hydrogen, C1-4 alkyl, lower acyl, benzyl, or SO2R5; R5 is C1-4 alkyl or benzyl; W is oxygen, a secondary nitrogen atom (NH), or sulfur; and * represents an asymmetric carbon atom.