A FROG SKIN ANTIBACTERIAL PEPTIDE DERIVATIVE

摘要

The present invention relates to a frog skin antibacterial peptide derivative having antibacterial function and to its salt which is suitable for medicamental use, which structural formula is: Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-X-Asn-Y-OH Wherein the "X" is select from amino acid residue Met or Ile or Leu, the "Y" contain two residues which select from Ser,Lys,Ile,Arg and Leu. The antibacterial function of the said derivatives is same as or more large than it of nature frog skin antibacterial peptide, and easily to be producted by solid phase chemosynthesis method, especially by geneticengineering technology.