OLIGONUCLEOTIDE COMPOSITIONS AND THEIR USE TO INDUCE APOPTOSIS

摘要

The present invention provides novel synthetic oligonucleotide sequences (hereinafter sequence) of3 to 9 bases in length comprising one or more non-D NA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases. These sequences optionally further comprise one or more guanine bases or one or more thymine bases, or combinations thereof. The present invention also provides for the use of these compositions in the medicaments and methods of using these compositions and medicaments to induce responses in cells, and to treat diseases and conditions characterized by undesired cellular proliferation su ch as autoimmune disease, lymphoproliferative disease, inflammation or cancer.< /SDOAB>