Disclosed are mutants of protein kinase B/Akt which can be crystallised in an enzymaticallyactive conformation, crystals of these mutants and X-ray coordinate data for the crystals.Also disclosed are methods of using the coordinate data provided for identification ofmodulators of protein kinase activity and for structural analysis of other proteinkinases, in particular AGC kinases.
申请公布号
WO03016517(A2)
申请公布日期
2003.02.27
申请号
WO2002GB03737
申请日期
2002.08.14
申请人
NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG FR;THE INSTITUTE OF CANCER RESEARCH;BARFORD, DAVID;YANG, JING;HEMMINGS, BRIAN, ARTHUR;CRON, PETER, DAVID
发明人
BARFORD, DAVID;YANG, JING;HEMMINGS, BRIAN, ARTHUR;CRON, PETER, DAVID