| 摘要 |
<p>A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formula [insert chemical structure] wherein R1 is -O-C(O)alkyl, -O-C(O)aryl or -O-C(O)cycloalkyl by contacting the mixture with a carboxylic ester hydrolase enzyme which catalyzes the stereoselective hydrolysis of the mixture and the use of such enantiomers to produce antitumor compounds which are especially suitable for oral administration.</p> |
