发明名称 |
VIRUS COAT PROTEIN/RECEPTOR CHIMERAS AND METHODS OF USE |
摘要 |
The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor. Such chimeric molecules therefore exhibit functional properties characteristic of a receptor-coat protein complex and are useful as agents that inhibit virus infection of cells due to occupancy of a co-receptor present on the cell. In particular aspects, the chimeric polypeptide includes an immunodeficiency virus envelope polypeptide, such as that of HN , SN, FIV, FeL V, FPV and herpes virus. Receptor sequences suitable for use in a chimeric polypeptide include, for example, CD4 DID2 and CD4M9 sequences. |
申请公布号 |
WO03016333(A2) |
申请公布日期 |
2003.02.27 |
申请号 |
WO2002US26543 |
申请日期 |
2002.08.21 |
申请人 |
UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE |
发明人 |
DEVICO, ANTHONY, L.;FOUTS, TIMOTHY, R.;TUSKAN, ROBERT, G. |
分类号 |
G01N33/50;A61K31/7088;A61K38/00;A61K39/00;A61K39/395;A61K48/00;A61P31/12;A61P31/18;C07K14/005;C07K14/155;C07K14/16;C07K14/705;C07K14/73;C07K16/08;C07K16/10;C07K16/28;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/62;C12Q1/02;C12Q1/70;G01N33/15;G01N33/53;G01N33/569 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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