HUMAN TOXICOLOGICALLY RELEVANT GENES AND ARRAYS

摘要

The invention provides for a set of toxicologically relevant human genes which may be used to predict toxicological responses on a cellular, organ, or system level. Methods of identifying, selecting, isolating, and evaluating toxicologically relevant human genes are provided. Arrays comprising human genes that are useful for toxicological screening of drugs, pharmaceutical compounds, or chemicals are also provided. The human array provides a method by which toxicological responses can analyzed in a rapid and efficient manner. Methods of identifying and isolating human genes for a human array are also provided. Further, methods of making a human gene array and using a human gene array are disclosed. These methods are also useful for isolating human genes and for discovery of novel human genes. Also provided is a database of human toxicological responses which are useful for predicting toxicological response to agents on a cellular level, organ-by-organ, and system-by-system. Methods of obtaining such databases containing human toxicological data and methods of use are also provided herein. Further, algorithms which allows for evaluation and/or 1 analysis of toxicological data are also provided herein.