β−KETOAMIDE COMPOUNDS AND MEDICINAL USE THEREOF

摘要

&bgr;−Ketoamide compounds represented by the following general formula [I]: [I] wherein each symbol is as defined in the description; pharmaceutically acceptable salts thereof and anti−HIV agents containing these compounds. Because of having an HIV integrase inhibitory activity, the above compounds are useful as anti−HIV agents to be used in remedies or preventives for AIDS. Further efficacious anti−HIV agents can be obtained by combining the compounds with other anti−HIV agents such as a protease inhibitor or a reverse transcriptase inhibitor. Because of showing a specifically high inhibitory activity on integrase, these compounds are usable as safe drugs with little side effects on the human body.