Modulators of Bruton'sTyrosine Kinase and Bruton's Tyrosine Kinase intermediates and methods for their identification and use in the treatment and prevention of osteoporosis and related diseases states

摘要

The present invention relates to the identification of Bruton's Tyrosine Kinase as a critical intermediate in the process of osteoclast activation, modulators of Bruton's Tyrosine Kinase, and assays for the identification of such modulators. It is now found that such modulators are useful in the treatment and prevention of osteoporosis and related disease states.