THE PROCESS FOR PREPARING ISOTONIC TOPICAL ANTIBIOTIC OPHTHALMIC FORMULATION WITH IMPROVED THERAPEUTIC EFFECT

摘要

Eye infections are responsible for ocular morbidity and mortality if not treated in time adequately. In country like India, infections account for majority of corneal blindness. Because of this reason, there is constantly a search going on for better antibiotics to be available for ophthalmic use. The preferred antibiotic should have broad spectrum of action. It should achieve therapeutic concentration when applied topically. It is also preferable to maintain therapeutic concentration for as long as period as possible necessitating fewer application of the drug and improved compliance. The present invention relates to process of preparation of isotonic topical ophthalmic antibiotic formulation of Sparfloxacin in such a way that it is stable at room temperature, achieves higher concentration, It also has low MIC against pathogen and so achieves higher therapeutic index. This antibiotic formulation also achieves better therapeutic results.