| 摘要 |
The invention provides methods for detection, diagnosis and monitoring of tumor cells in a sample of mammalian cells. In one aspect, the invention provides methods for detecting the protein, p38.5 expressed at the cell surface, where cell surface expression of p38.5 is indicative of a tumor cell, particularly of hematopoietic origin. In another aspect the invention provides methods of diagnosis of tumor cells by determining the total level of expression of p38.5 or p38.5-specific RNA, a higher than normal level of total p38.5 expression by the cells being diagnostic of tumor cells in a wide range of cell types. Methods of treating tumors expressing cell surface p38.5 are also provided. Also described are screening methods for identifying compounds that inhibit NK mediated cytotoxicity.
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