摘要 |
Orally nonabsorbed or poorly absorbed drugs may be converted to orally absorbed prodrug derivatives by derivatization of free functional groups selected from amino, hydroxyl, mercapto, phosphate and/or carboxyl with groups sensitive to mild basic conditions such as 9-fluorenylmethoxycarbonyl (Fmoc), 2-sulfo-9-fluorenylmethoxycarbonyl (Fms), and fluorenylmethyl (Fm). |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD.;SHECHTER, YORAM;GOLDWASER, ITZHAK;LAVON, IRIS;BRODIE, DAVID;EYAL, NURIT;FASS, STANLEY;FRIDKIN, MATITYAHU |
发明人 |
SHECHTER, YORAM;GOLDWASER, ITZHAK;LAVON, IRIS;BRODIE, DAVID;EYAL, NURIT;FASS, STANLEY;FRIDKIN, MATITYAHU |