A model structure of IIIb of the hepatitis C virus internal ribosome entry site has been elucidated. The invention provides an in silico methods for identifying a compound that interacts with IIIb. Suitable methods include de novo compound design, use of the pharmacophore, and automated docking algorithms. Uses of compound/s identified are also described.
申请公布号
WO03017197(A2)
申请公布日期
2003.02.27
申请号
WO2002GB03767
申请日期
2002.08.13
申请人
RIBO TARGETS LIMITED;ABOUL-ELA, FAREED;KLINCK, ROSCOE;GALLEGO, JOSE;VARANI, GABRIELE;WALKER, STEPHEN
发明人
ABOUL-ELA, FAREED;KLINCK, ROSCOE;GALLEGO, JOSE;VARANI, GABRIELE;WALKER, STEPHEN