发明名称 |
ANTISENSE MODULATION OF PTEN EXPRESSION |
摘要 |
<p>Antisense compounds, compositions and methods are provided for modulating the expression of PTEN. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTEN. Methods of using these compounds for modulation of PTEN expression and for treatment of diseases and conditions associated with expression of PTEN are provided. Such conditions include diabetes and hyperproliferative conditions. Methods for decreasing blood glucose levels, inhibiting PEPCK expression, decreasing blood insulin levels, decreasing insulin resistance, increasing insulin sensitivity, decreasing blood triglyceride levels or decreasing blood cholesterol levels in an animal using the compounds of the invention are also provided. The animal is preferably a human; also preferably the animal is a diabetic animal.</p> |
申请公布号 |
EP1285061(A1) |
申请公布日期 |
2003.02.26 |
申请号 |
EP20010935740 |
申请日期 |
2001.05.21 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
MONIA, BRETT, P.;COWSERT, LEX, M.;MCKAY, ROBERT |
分类号 |
C12N15/09;A61K31/7088;A61K31/711;A61K31/712;A61K31/7125;A61K38/00;A61K48/00;A61P3/00;A61P3/10;A61P43/00;C12N15/113;C12Q1/02;C40B20/08;C40B40/06;C40B50/14;(IPC1-7):C12N15/00;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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