ANTICANCER AGENT-CHITOSAN COMPLEX FORMING SELF-AGGREGATE AND PRODUCTION THEREOF

摘要

PURPOSE: Provided is a complex capable of forming a spherical self-aggregate similar to a micelle in an aqueous system by amphiphilicity containing both a hydrophobic group of an anticancer agent and a hydrophilic group of chitosan, thereby allowing a sustained release of the drug and increasing selectivity to cancer tissue. CONSTITUTION: The anticancer agent-chitosan complex having a diameter of 10 to 800nm comprises 1 to 70% by weight of a hydrophobic anticancer agent and hydrophilic chitosan having an average molecular weight of 10¬3 to 10¬6 and additionally a linker which is decomposed in an acid. The hydrophobic anticancer agent is selected from the group consisting of adriamycin, taxol, cis-platin, mitomycin-C, daunomycin and 5-fluorouracil.