发明名称 STABILIZED PHARMACEUTICAL COMPOSITIONS CONTAINING THE CALCIUM CHANNEL BLOCKER AZELNIDIPINE
摘要 <p>The present invention provides a pharmaceutical composition containing a calcium blocker of the following formula or a pharmacologically acceptable salt thereof and a pharmacologically acceptable alkaline material which is added to an extent such that an aqueous solution or dispersion solution of said pharmaceutical composition containing a calcium blocker has a pH of at least 8: &lt;CHEM&gt; Äwherein R&lt;1&gt; represents an optionally substituted C1-C4 alkyl group, an amino group or a cyano group; R&lt;2&gt; represents an optionally substituted C1-C4 alkyl group, a substituted C3-C4 alkenyl group, or a substituted 4- to 6-membered cyclic amino group; R&lt;3&gt; represents a substituted phenyl group; R&lt;4&gt; represents an optionally substituted C1-C4 alkoxycarbonyl group, a 1,3,2-phosphorinan-2-yl group, or a 5,5-dimethyl-1,3,2-phosphorinan-2-yl group, R&lt;5&gt; represents a C1-C4 alkyl groupÜ.</p>
申请公布号 EP1285655(A1) 申请公布日期 2003.02.26
申请号 EP20010919870 申请日期 2001.04.10
申请人 SANKYO COMPANY, LIMITED 发明人 WAKIYAMA, NAOKI;USUI, FUSAO;NISHIMURA, KENJI
分类号 A61K31/4422;A61K9/20;A61K31/4418;A61K31/4427;A61K31/443;A61K31/4439;A61K31/444;A61K31/4545;A61K31/496;A61K31/675;A61K47/02;A61P9/12;C07D211/90;C07D401/06;C07F9/6571;(IPC1-7):A61K31/442;A61K31/442;C07F9/59;C07D405/06;C07D211/92;A61K31/454 主分类号 A61K31/4422
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