INFUSION OF CIPROFLOXACIN HAVING REDUCED ACID CONTENT AND BEING STABLE ON STORAGE

摘要

The invention relates to infusions of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-o xo- 7-(1-piperazinyl)-quinoline-3-carboxylic acid (ciprofloxacin) which are stab le in storage and which can be obtained by mixing between 0.015 and 0.5 g of active ingredient for 100 ml of aqueous solution with sulphuric acid or sodi um hydrogen sulfate in a quantity equal to or less than 0.96 mole per mole of active ingredient, sufficient for dissolving the active ingredient and stabilising the solution. The invention also relates to methods for producin g the infusions and the use thereof. The inventive infusions enable the acid content to be reduced, are more stable in storage with the same acid content than other known solutions, and enable a larger proportion of secondary components to be tolerated in the active ingredient than previous standard infusions of ciprofloxacins.