摘要 |
Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule. |
申请人 |
AMERICAN CYANAMID COMPANY;GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES;GREEN, BRUCE, A.;HOLMES, RANDALL, K.;JOBLING, MICHAEL, G.;ZHU, DUZHANG |
发明人 |
GREEN, BRUCE, A.;HOLMES, RANDALL, K.;JOBLING, MICHAEL, G.;ZHU, DUZHANG |