THE NATURAL LIGAND FOR ORPHAN G PROTEIN COUPLED RECEPTOR GPR86 AND METHODS OF USE

摘要

The present invention is related to the G protein coupled receptor GPR86 (P2Y13) and any homologous sequence thereto, recombinant cells comprising th e nucleotide sequence encoding the receptor, and the identification of the natural ligand, ADP, and equivalent molecules to be used in screening assays for identification of agonists, inverse agonists or antagonist compounds useful for the development of new drugs and the improvement of various disea se diagnostics. The present invention further relates to the identification of ATP, 2MeSATP, 2MeSADP, ADP.beta.S, Ap3A, RB-2, Suramine and PPADS as modulators of GPR86 activity.