PEPTIDE FRAGMENTS OF BASIC PROTEIN MYELIN, PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF AND APPLICATION OF THESE COMPOSITIONS FOR TREATMENT OF CEREBROSPINAL SCLEROSIS

摘要

FIELD: organic chemistry, proteins, biochemistry. SUBSTANCE: invention describes peptide of the formula: Asp-Glu-Asn-Pro-Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr- - Pro-Arg-Thr that is able to neutralize or modulate formation of antimyelin basic protein. Peptide can be used for treatment of patients with cerebrospinal sclerosis and it exhibits the more activity as compared with that of myelin basic protein. Peptide does not exhibit toxicity and immunogenic properties. Invention describes also pharmaceutical composition comprising peptide and method of treatment of patients with cerebrospinal sclerosis. EFFECT: improved method of treatment, valuable medicinal properties of peptide and composition. 8 cl, 4 tbl, 35 dwg, 10 ex