摘要 |
The present invention relates to the use of irinotecan or a derivative there of for the preparation of a pharmaceutical composition for treating colorectal cancer, cervical cancer, gastric cancer, lung cancer, malignant glioma, ovarian cancer, and pancreatic cancer in a patient having a genotype with a varient allele which comprises a polynucleotide in accordance with the prese nt invention. Preferably, a nucleotide deletion, addition and/or substitution comprised by said polynucleotide results in a altered expression of a varian t allele compared to the corresponding wild type allele or an altered activity of the polypeptide encoded by the variant allele compared to the polypeptide encoded by the corresponding wild type allele. Finally, the present inventio n relates to a method for selecting a suitable therapy for a subject suffering from colorectal cancer, cervical cancer, gastric cancer, lung cancer, malignant glioma, ovarian cancer, and pancreatic cancer. |