Simultaneous determination of phenotype and genotype

摘要

The invention provides antibody which can bind to an antigen present in a heme-containing cell and to which a fluorophore with an emission wavelength of between 420 nm and 500 nm is bound. The antibody of the invention can bind to an antigen of interest in a heme-containing cell and, due to the fluorophore, the binding interaction can be visualized. This facilitates the use of fluorescent labels for immunophenotyping of red blood cells and, in particular, fetal red blood cells within a blood sample from a pregnant female. It also facilitates simultaneous use of immunophenotyping and fluorescence-based nucleic acid analytical techniques such as FISH. Genotype and phenotype can be detected at the same time.