摘要 |
<p>[2 + 2] photo-attachable functional groups were incorporated in polyacrylamide based hydrogels and synthetic oligonucleotide probes. The probes were photochemically attached by covalent bonding to the three dimensional surface of a hydrogel. The resultant hydrogel microarrays were used for detection of specific target oligonucleotides, including mRNA and DNA, as suitable for expression and single nucleotide polymorphism type microarray analyses.</p> |