REMEDIES FOR HEART DISEASES

摘要

It is intended to provide a method of searching for a substance capable of selectively inhibiting apoptosis in heart/vascular cells. The above object can be achieved by providing a method of screening a remedy for heart diseases and/or a preventive for heart diseases characterized by comprising: the step of inducing apoptosis of cultured heart muscular cells and/or cultured vascular endothelial cells; the step of treating the cells with a Cl− channel inhibitor which is a test substance; and the step of evaluating the therapeutic and/or preventive effects of the test substance on heart diseases based on its effect of inhibiting the apoptotic cell death of the muscular cells and/or vascular endothelial cells.