发明名称 |
MUTATED MHC MOLECULES FOR USE IN IMMUNE SUPPRESSION |
摘要 |
The invention provides immunocomplex comprising MHC molecules or functional fragments thereof which are modified so as to prevent binding to co-receptors e.g. CD8 or CD4. The inventors have determined that inability of the MHC complex to bind co-receptor leads to death of the T-cells without delivery of an activation/proliferation signal. By associating the immunocomplex with a specific peptide antigen it is possible to selectively suppress the immune system of a host, i.e. to help prevent tissue rejection or treat autoimmune diseases. For a more universal suppression of the immune system, it is possible to administer the modified MHC complex or fragment/component thereof in the absence of peptide antigen. For example, modified beta M complex can be administered. |
申请公布号 |
WO02074331(A3) |
申请公布日期 |
2003.02.20 |
申请号 |
WO2002GB01337 |
申请日期 |
2002.03.19 |
申请人 |
ISIS INNOVATION LIMITED;SCREATON, GAVIN;XU, XIAONING |
发明人 |
SCREATON, GAVIN;XU, XIAONING |
分类号 |
A61K38/00;A61K39/00;A61P37/06;C07K14/74 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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