IMPROVED FORMS OF PHARMACEUTICALLY ACTIVE AGENTS AND METHOD FOR MANUFACTURE THEREOF

摘要

A pharmaceutical composition comprising a pharmaceutically active agent and a salt of said pharmaceutically active agent with the proviso that said composition does not contain hydrolyzed cellulose, wherein said pharmaceutical active agent is a weak acid or weak base. The present invention is also directed to a new ibuprofen form having, when potassium is present in said form as a counter ion, an IR peak at 1706 cm<-1> shifted and broadened in absorbance relative to racemic ibuprofen free acid, the form's characteristic absorbance profile from 1000 to 650 cm<-1> and broadened in absorbance relative to racemic ibuprofen free acid, the form's characteristic absorbance profile from 1000 to 650 cm<-1> and D-spacings of 21.1, 7.1, and 3.4 ANGSTROM by X-ray diffraction.