| 发明名称 |
SPHKS AS MODIFIERS OF THE P53 PATHWAY AND METHODS OF USE |
| 摘要 |
Human SPHK genes are identified as modulators of the p53 pathway, and thus a re therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPHK are provided.
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| 申请公布号 |
CA2454514(A1) |
申请公布日期 |
2003.02.20 |
| 申请号 |
CA20022454514 |
申请日期 |
2002.08.02 |
| 申请人 |
EXELIXIS, INC. |
发明人 |
HUNG, TAK;FUNKE, ROEL P.;COSTA, MICHAEL A.;LI, DANXI;PLOWMAN, GREGORY D.;FRIEDMAN, LORI |
| 分类号 |
C12N15/09;A61K31/7052;A61K31/7088;A61K31/7105;A61K38/00;A61K39/395;A61K45/00;A61P9/00;A61P35/00;A61P43/00;C12Q1/02;C12Q1/48;C12Q1/68;G01N33/15;G01N33/50;G01N33/574;G01N33/68;(IPC1-7):C12Q1/48;G01N33/573 |
主分类号 |
C12N15/09 |
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