| 发明名称 |
DNA encoding bradykinin B1 receptor |
| 摘要 |
DNAs encoding bradykinin B1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind des-Arg10 kallidin and other B1-specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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| 申请公布号 |
US2003036633(A1) |
申请公布日期 |
2003.02.20 |
| 申请号 |
US20010007343 |
申请日期 |
2001.10.22 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
LINEMEYER DAVID L.;HESS JOHN W.;BORKOWSKI JOSEPH A.;BIERILO KATHLEEN K.;MENKE JOHN G. |
| 分类号 |
C12N15/09;A61K38/00;A61K45/00;A61K48/00;A61P9/02;A61P25/04;A61P29/00;A61P43/00;C07K14/72;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12Q1/00;(IPC1-7):C07K14/705;C12P21/02;C12N5/06;C07H21/04 |
主分类号 |
C12N15/09 |
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