摘要 |
<p>Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administrating to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemoplilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor other than in a liposome, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject.</p> |
申请人 |
THE GOVERNMENT OF THE UNITED STATE OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.;ALPAN, ORAL;KAMALA, TIRUMALAI;MATZINGER, POLLY;VELANDER, WILLIAM, HUGOLD |
发明人 |
ALPAN, ORAL;KAMALA, TIRUMALAI;MATZINGER, POLLY;VELANDER, WILLIAM, HUGOLD |