| 发明名称 |
DIAGNOSTICS AND THERAPEUTICS FOR GLAUCOMA |
| 摘要 |
<p>This invention provides methods and compositions for diagnosing and treating glaucoma based on determining the level of a Frizzle Related Protein (FRP), a component of the wingless (Wnt) signaling pathway. The method can include the detection of a genetic lesion like polymorphic allele (e.g. FRP promoter, ...) for diagnosing glaucoma. This invention also discloses the use of transgenic animals for the study of glaucoma (screening for therapeutics, animal disease model, ...).</p> |
| 申请公布号 |
WO0164949(A9) |
申请公布日期 |
2003.02.20 |
| 申请号 |
WO2001US06100 |
申请日期 |
2001.02.26 |
| 申请人 |
ALCON LABORATORIES, INC. |
发明人 |
CLARK, ABBOT, F.;FINGERT, JOHN;MCNATT, LORETTA;STONE, EDWIN, M.;WANG, WAN-HENG |
| 分类号 |
A61K31/7088;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P27/06;C07K14/47;C12N9/12;C12N15/09;C12Q1/02;C12Q1/48;C12Q1/68;G01N33/15;G01N33/50;G01N33/68;(IPC1-7):C12Q1/68;A01K67/027;A61K31/70;C12N9/00;C12N15/00 |
主分类号 |
A61K31/7088 |
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