| 摘要 |
The present invention provides methods and compositions for modulating the phosphorylation of DARPP-32 in a serotonergic receptor intracellular signali ng pathway. The invention provides methods and compositions for modulating the activities of protein phosphatase-1 (PP-1), protein phosphatase 2C (PP2C), protein phosphatase 2B (PP2B) and/or protein phosphatase 2a (PP2A) in cells or tissues. The invention provides methods of treating sertonergic intracellula r signaling pathway disorders, e.g., depression. The invention provides method s of treating dopamine-related disorders. The invention provides methods of identifying agents that modulate the activities of serotonergic receptor intracellular signaling molecules, DARPP-32, casein kinase 1, cyclin-depende nt kinase 5, AMPA receptors, protein phosphatase-1, protein phosphatase 2C, protein phosphatase 2B and/or protein phosphatase 2A, for use in such treatments. The invention also provides methods of modulating phosphorylatio n- dependent activation of AMPA receptors for use in such treatments.
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