AQUEOUS DISPERSION COMPRISING STABLE NANOPARTICLES OF A WATER-INSOLUBLE ACTIVE AND AN EXCIPIENT LIKE MIDDLE CHAIN TRIGLYCERIDES (MCT)

摘要

A process for the preparation of a stable dispersion of solid particles, in an aqueous medium comprising combining (a) a first solution comprising a substantially water-insoluble substance, a water-miscible organic solvent an d an inhibitor with (b) an aqueous phase comprising water and optionally a stabiliser, thereby precipitating solid particles comprising the inhibitor a nd the substantially water-insoluble substance; and optionally removing the wat er- miscible organic solvent; wherein the inhibitor is a non-polymeric hydrophob ic organic compound as defined in the description. The process provides a dispersion of solid particles in an aqueous medium, which particles exhibit reduced or substantially no particle growth mediated by Ostwald ripening.